|
Adverse reactions to Dapsone |
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| System |
Manifestations |
Mechanisms |
|
|
||
| Systemic |
||
| • *DHS |
Dermatitis, hepatitis |
Idisosyncratic |
| • **DRESS syndrome |
Dermatitis, eosinophilia |
Idiosyncratic |
| • Nonspecific |
Nausea, headache, dizzy Weakness/fatigue |
Predictable |
| Hematological |
Hemolytic anemia |
Predictable (G6PDD) |
| Methemoglobinemia |
Predictable |
|
| Neurological |
Peripheral neuropathy |
Predictable |
| Dermatological |
Stevens-Johnson Syndrome |
Idiosyncratic |
| Toxic epidermal necrolysis |
Idiosyncratic |
|
| Hepatic |
Colestasis, hepatitis |
Idiosyncratic |
| Renal |
Nephritis |
Idiosyncratic |
| Pulmonary |
Pneumonitis, ***PIE |
Idiosyncratic |
| Thyroid |
Hypothyroidism |
Idiosyncratic |
|
DHS = dapsone hypersensitivity syndrome, DRESS = drug rash, eosinophilia and systemic symptoms, PIE = pulmonary infiltration with eosinophilia | ||
Kosseifi et al. Journal of Occupational Medicine and Toxicology 2006 1:9 doi:10.1186/1745-6673-1-9 |
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