Table 6

Treatment approaches to DHS

Intervention

Comments

1. Withdrawal of offending medication (dapsone)

Drug discontinuation

2. Supportive therapy

• Volume replacement

Intravenous fluid replacement

• Nutritional support

Enteral or parenteral nutrition

• Antibiotics

Early antibiotic institution in case of concomitant sepsis

• Skin care

Preventing skin superinfection

3. Specific therapy

• Glucocorticoids

Recommended dose 1 mg/kg/day

• Thyroid hormone replacement

Associated late hypothyroidism

• Family counseling

Genetic factors involvement

Kosseifi et al. Journal of Occupational Medicine and Toxicology 2006 1:9   doi:10.1186/1745-6673-1-9