Email updates

Keep up to date with the latest news and content from JOMT and BioMed Central.

Open Access Highly Accessed Open Badges Review

A compendium of causative agents of occupational asthma

Xaver Baur

Journal of Occupational Medicine and Toxicology 2013, 8:15  doi:10.1186/1745-6673-8-15

PubMed Commons is an experimental system of commenting on PubMed abstracts, introduced in October 2013. Comments are displayed on the abstract page, but during the initial closed pilot, only registered users can read or post comments. Any researcher who is listed as an author of an article indexed by PubMed is entitled to participate in the pilot. If you would like to participate and need an invitation, please email, giving the PubMed ID of an article on which you are an author. For more information, see the PubMed Commons FAQ.

An experimental approach to confirm that an occupational agent causes asthma

Jean-Luc Malo   (2013-07-31 11:55)  H��pital du Sacr��-Coeur de Montr��al email

I read with great interest the article by Baur in the J Occup Med Toxicol. 2013; 8: 15. A compendium of causative agents of occupational asthma.
I fear that the method of assessment used by the author, an evidence-based approach, is not appropriate.
Most of the agents that cause occupational asthma have been identified by an experimental approach through specific inhalation challenge in which the subject is exposed to a control substance and the active agent with objective testing (serial assessment of airway calibre).
Using such an experimental approach, even if an agent has been found to cause occupational asthma in only one subject, the evidence is sufficient to incriminate this agent in the list of agents causing occupational asthma.
Many thanks.

Jean-Luc Malo MD
Department of Chest Medicine
H��pital du Sacr��-Coeur de Montr��al
5400 West, Gouin Blvd., Montr��al, Canada H4J 1C5

Competing interests

I have no competing interest.


Post a comment